What jaundice means
- Before the liver: accelerated red-cell breakdown (haemolysis) can raise unconjugated bilirubin.
- Within the liver: viral, alcohol-related, metabolic, autoimmune, ischaemic or medicine/supplement-related injury can impair bilirubin processing.
- After the liver: gallstones, bile-duct narrowing, pancreatitis or tumours can block bile flow and often cause dark urine, pale stools and itching.
- Mild isolated bilirubin elevation may have a benign explanation such as Gilbert syndrome, but this should be distinguished from dangerous causes rather than self-diagnosed.
New yellowing of the eyes or skin in an adult warrants urgent clinical advice. Jaundice in a newborn follows a separate paediatric pathway and requires prompt bilirubin assessment.